Psychedelics
DE Nichols - Pharmacological reviews, 2016 - ASPET
Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter
perception and mood and affect numerous cognitive processes. They are generally …
perception and mood and affect numerous cognitive processes. They are generally …
Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development
SP McCluskey, C Plisson, EA Rabiner… - European journal of …, 2020 - Springer
Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …
Brain serotonin release is reduced in patients with depression: a [11C] Cimbi-36 positron emission tomography study with a d-amphetamine challenge
D Erritzoe, BR Godlewska, G Rizzo, GE Searle… - Biological …, 2023 - Elsevier
Background The serotonin hypothesis of depression proposes that diminished serotonergic
(5-HT) neurotransmission is causal in the pathophysiology of the disorder. Although the …
(5-HT) neurotransmission is causal in the pathophysiology of the disorder. Although the …
Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2, 5-dimethoxy-substituted phenethylamines (2C drugs)
Abstract Background N-2-methoxybenzyl-phenethylamines (NBOMe drugs) are newly used
psychoactive substances with poorly defined pharmacological properties. The aim of the …
psychoactive substances with poorly defined pharmacological properties. The aim of the …
Chemistry and structure–activity relationships of psychedelics
DE Nichols - Behavioral Neurobiology of Psychedelic Drugs, 2018 - Springer
This chapter will summarize structure–activity relationships (SAR) that are known for the
classic serotonergic hallucinogens (aka psychedelics), focusing on the three chemical types …
classic serotonergic hallucinogens (aka psychedelics), focusing on the three chemical types …
Toxicities associated with NBOMe ingestion—a novel class of potent hallucinogens: a review of the literature
Background A new class of synthetic hallucinogens called NBOMe has emerged as drugs of
abuse. Objective Our aim was to conduct a systematic review of published reports of …
abuse. Objective Our aim was to conduct a systematic review of published reports of …
5‐HT radioligands for human brain imaging with PET and SPECT
The serotonergic system plays a key modulatory role in the brain and is the target for many
drug treatments for brain disorders either through reuptake blockade or via interactions at …
drug treatments for brain disorders either through reuptake blockade or via interactions at …
The NBOMe hallucinogenic drug series: Patterns of use, characteristics of users and self-reported effects in a large international sample
The NBOMe compounds are a novel series of hallucinogenic drugs that are potent agonists
of the 5-HT2A receptor, have a short history of human consumption and are available to buy …
of the 5-HT2A receptor, have a short history of human consumption and are available to buy …
Pharmacology and Toxicology of N-Benzylphenethylamine (“NBOMe”) Hallucinogens
AL Halberstadt - … of New Psychoactive Substances (NPS) The Science …, 2017 - Springer
Serotonergic hallucinogens induce profound changes in perception and cognition. The
characteristic effects of hallucinogens are mediated by 5-HT 2A receptor activation. One …
characteristic effects of hallucinogens are mediated by 5-HT 2A receptor activation. One …
25C-NBOMe–new potent hallucinogenic substance identified on the drug market
D Zuba, K Sekuła, A Buczek - Forensic science international, 2013 - Elsevier
This publication reports analytical properties of a new hallucinogenic substance identified in
blotter papers seized from the drug market, namely 25C-NBOMe [2-(4-chloro-2, 5 …
blotter papers seized from the drug market, namely 25C-NBOMe [2-(4-chloro-2, 5 …