Defatted Wheat Germ Protein-Derived Peptides Showed Multiple Biological Activities from the Stomach to Small Intestine: In Silico and In Vitro Approaches

BGK Madhavi, AM Wijethunga… - Journal of Agricultural …, 2024 - ACS Publications
This study aimed to test the hypothesis that bioactive peptides can exert multiple bioactivities
at different sites in the gastrointestinal tract. Our previous research identified 33 gastric …

A novel angiotensin I-converting enzyme inhibitory peptide APPLRP from Grifola frondosa ameliorated the Ang II-induced vascular modeling in zebrafish model by …

T Song, T Zhang, Q Cai, YY Ding, Z Gu - International Journal of Biological …, 2024 - Elsevier
Grifola frondosa has garnered significant popularity as an edible mushroom attributable to
its exceptional taste and nutritional benefits. This study isolated APPLRP, a potent ACE …

In Silico Screening of Bioactive Peptides in Stout Beer and Analysis of ACE Inhibitory Activity

W Tian, C Zhang, Q Zheng, S Hu, W Yan, L Yue… - Foods, 2024 - mdpi.com
Stout beer was selected as the research object to screen angiotensin-converting enzyme
(ACE) inhibitory peptides. The peptide sequences of stout beer were identified using ultra …

Computational Modeling of the Interactions between DPP IV and Hemorphins

P Antony, B Baby, A Jobe, R Vijayan - International journal of molecular …, 2024 - mdpi.com
Type 2 diabetes is a chronic metabolic disorder characterized by high blood glucose levels
due to either insufficient insulin production or ineffective utilization of insulin by the body …

Bioactive peptides (cryptides) obtained by Bothrops jararaca serine peptidases action on myoglobin

AVV Auada, MVA Falla, I Lebrun - Toxicon, 2024 - Elsevier
Serine peptidases and metallopeptidases are the primary toxins found in Bothrops snakes
venoms, which act on proteins in the tissues of victims or prey, and release of peptides …

[HTML][HTML] Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

P Antony, B Baby, R Vijayan - Frontiers in Molecular …, 2024 - pmc.ncbi.nlm.nih.gov
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of
hemoglobin. They have received considerable attention recently due to their interaction with …

Synthesis, characterization, and biological study of new synthetic opioid hemorphin‐4 peptides containing sterically restricted nonnatural amino acids

P Todorov, S Georgieva, C Trapella… - Archiv der …, 2024 - Wiley Online Library
Some new hemorphin‐4 analogs with structures of Xxx‐Pro‐Trp‐Thr‐NH2 and Tyr‐Yyy‐Trp‐
Thr‐NH2, where Xxx is 2‐amino‐3‐(4− hydroxy‐2, 6‐dimethylphenyl) propanoic acid or 2 …