Lapachol and its congeners as anticancer agents: a review

F Epifano, S Genovese, S Fiorito, V Mathieu… - Phytochemistry …, 2014 - Springer
Lapachol is a naturally occurring 1, 4-naphthoquinone originally isolated by the Italian
phytochemist E. Paterno from Tabebuia avellanedae (Bignoniaceae) in 1882 and …

Strategies for increasing the solubility and bioavailability of anticancer compounds: β-lapachone and other naphthoquinones

V Francisco Ferreira… - Current …, 2016 - ingentaconnect.com
Quinones are among the most studied natural and synthetic products in the literature
because they have considerable biological potential. These compounds exhibit activity …

Cytotoxicity of lapachol metabolites produced by probiotics

EO Silva, TC de Carvalho, IA Parshikov… - Letters in Applied …, 2014 - academic.oup.com
Probiotics are currently added to a variety of functional foods to provide health benefits to the
host and are commonly used by patients with gastrointestinal complaints or diseases. The …

Fluorescent oxazoles from quinones for bioimaging applications

GG Dias, PVB Pinho, HA Duarte, JM Resende… - RSC …, 2016 - pubs.rsc.org
This work describes a synthetic strategy for the syntheses of four new fluorescent excited
state intramolecular proton transfer (ESIPT) prone oxazole derivatives synthesized from …

Leishmanicidal effects of piperlongumine (piplartine) and its putative metabolites

F de Lima Moreira, TB Riul, M de Lima Moreira… - Planta …, 2018 - thieme-connect.com
Piperlongumine is an amide alkaloid found in Piperaceae species that shows a broad
spectrum of biological properties, including antitumor and antiparasitic activities. Herein, the …

Oxidation Products from the Neolignan Licarin A by Biomimetic Reactions and Assessment of in vivo Acute Toxicity

JNP e Souza, RM da Silva, SS Fortes… - Planta …, 2023 - thieme-connect.com
Licarin A, a dihydrobenzofuranic neolignan presents in several medicinal plants and seeds
of nutmeg, exhibits strong activity against protozoans responsible for Chagas disease and …

Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid …

TB Gontijo, RP de Freitas, GF de Lima… - Chemical …, 2016 - pubs.rsc.org
For the first time, a fluorescent lapachone-based BODIPY was synthesised and
characterised by NMR and mass spectrometry. Computational and electrochemical aspects …

Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

Z Cheng, WO Valenca, GG Dias, J Scott… - Bioorganic & Medicinal …, 2019 - Elsevier
Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based
probes for imaging NAD (P) H: quinone oxidoreductase (NQO1) in cancer cells and tumour …

New prenylated dihydrochalcones from the leaves of Artocarpus elasticus

M Daus, P Chaithada, S Phongpaichit… - Phytochemistry …, 2017 - Elsevier
The leaves of Artocarpus elasticus collected in Thailand were investigated for chemical
constituents. Four new prenylated dihydrochalcones named elastichalcones C, D, E, F (1, 3 …

In vitro metabolism studies of erythraline, the major spiroalkaloid from Erythrina verna

T Guaratini, DB Silva, AC Bizaro, LR Sartori… - … and alternative medicine, 2014 - Springer
Background Erythrina verna, popularly known as “mulungu”, is a Brazilian medicinal plant
used to treat anxiety. Erythrina alkaloids have been described in several species of …