Reviewing the advancements in malaria treatment, the emergence of triazole hybrid
compounds stands out as a groundbreaking development. Combining the advantages of …

Abstract The ESKAPE (Escherichia coli/E. coli, Staphylococcus aureus/S. aureus, Klebsiella
pneumonia/K. pneumoniae, Acinetobacter Baumannii/A. baumannii, Pseudomonas …

ESKAPE pathogens, as priority 1 and 2 pathogens, are prevalent infectious agents
associated with high morbidity and mortality. ESKAPE can cause broad-spectrum diseases …

Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to
DNA substrates and is a clinically-relevant target for the development of new antibacterials …

The discovery of small organic molecules as new antimicrobial agents is a promising
strategy for encountering the problem of multidrug-resistant microbial strains. In an attempt …

The development of divergent methods to expedite structure–activity relationship studies is
crucial to streamline discovery processes. We developed a rare example of regiodivergent …

Candida infections are most prominent among fungal infections majorly target
immunocompromised and hospitalized patients and cause significant morbidity and …

With the aim to identify new antiviral agents with antibacterial properties, a series of 2-
quinolone-1, 2, 3-triazole derivatives bearing α-aminophosphonates was synthesized and …

In this investigation, a series of 2-quinolone-benzimidazole hybrids linked by a 1, 2, 3-
triazole moiety were prepared using copper-catalyzed Huisgen 1, 3-dipolar cycloaddition …

This study reports the synthesis of 2-thioxo-1, 3-dithiol-carboxamides (TDTCAs) under mild
conditions at room temperature using HBTU as a coupling agent, which significantly …