Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes
The large majority of lymphocytes belong to the adaptive immune system, which are made
up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response …
up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response …
[HTML][HTML] The dialogue between unconventional T cells and the microbiota
Q Lin, M Kuypers, DJ Philpott, T Mallevaey - Mucosal Immunology, 2020 - Elsevier
The mammalian immune system is equipped with unconventional T cells that respond to
microbial molecules such as glycolipids and small-molecule metabolites, which are invisible …
microbial molecules such as glycolipids and small-molecule metabolites, which are invisible …
Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury
CF Aguiar, F Corrêa-da-Silva, MB Gonzatti… - Cell reports, 2023 - cell.com
Invariant natural killer T (iNKT) cells are a distinct population of lymphocytes characterized
by their reactivity to glycolipids presented by CD1d. iNKT cells are found throughout the …
by their reactivity to glycolipids presented by CD1d. iNKT cells are found throughout the …
Invariant natural killer T cells minimally influence gut microbiota composition in mice
Q Lin, M Kuypers, Z Liu, JK Copeland, D Chan… - Gut …, 2022 - Taylor & Francis
ABSTRACT Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to
glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate …
glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate …
Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion
A Díaz-Basabe, G Lattanzi, F Perillo, C Amoroso… - Gut …, 2024 - Taylor & Francis
The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a
pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences …
pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences …
[HTML][HTML] The intestinal microbiota modulates the transcriptional landscape of iNKT cells at steady-state and following antigen exposure
Q Lin, M Kuypers, Y Baglaenko, E Cao, K Hezaveh… - Mucosal …, 2024 - Elsevier
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to microbe-
derived glycolipid antigens. iNKT cells exert fast innate effector functions that regulate …
derived glycolipid antigens. iNKT cells exert fast innate effector functions that regulate …
[HTML][HTML] Advanced omics techniques shed light on CD1d-mediated lipid antigen presentation to iNKT cells
I Morris, CA Croes, M Boes, E Kalkhoven - Biochimica et Biophysica Acta …, 2023 - Elsevier
Invariant natural killer T cells (iNKT cells) can be activated through binding antigenic
lipid/CD1d complexes to their TCR. Antigenic lipids are processed, loaded, and displayed in …
lipid/CD1d complexes to their TCR. Antigenic lipids are processed, loaded, and displayed in …
Specific and shared biological functions of PARP2–is PARP2 really a lil'brother of PARP1?
PARP2, that belongs to the family of ADP-ribosyl transferase enzymes (ART), is a discovery
of the millennium, as it was identified in 1999. Although PARP2 was described initially as a …
of the millennium, as it was identified in 1999. Although PARP2 was described initially as a …
Lack of mTORC2 signaling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
A Ignacio, M Cipelli, T Takiishi… - Journal of Leukocyte …, 2024 - academic.oup.com
The mammalian target of rapamycin (mTOR) pathway plays a key role in determining
immune cells function through modulation of their metabolic status. By specific deletion of …
immune cells function through modulation of their metabolic status. By specific deletion of …
iNKT cel transfer: The use of cell sorting combined with flow cytometry validation approach
M Cipelli, T Ramalho, CF de Aguiar… - Invariant Natural Killer T …, 2021 - Springer
Natural killer T (NKT) cells are an innate-like T cell subset that recognize lipid antigens
presented by CD1d-expressing antigen presenting cells (APCs), such as dendritic cells …
presented by CD1d-expressing antigen presenting cells (APCs), such as dendritic cells …