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The pig is an omnivorous, monogastric species with many advantages to serve as an animal
model for human diseases. There are very high similarities to humans in anatomy and …

Background Xenotransplantation using pig cells, tissues, or organs may be associated with
the transmission of porcine microorganisms and the development of zoonoses. Among all …

Xenotransplantation of pig islet cells is a promising alternative for the treatment of diabetes
with insulin and may help to prevent numerous late complications such as blindness and …

Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and
some of them are able to infect human cells. Therefore, PERVs pose a risk for …

Xenotransplantation may be a solution to overcome the shortage of organs for the treatment
of patients with organ failure, but it may be associated with the transmission of porcine …

Transgenic pigs are promising donor organisms for xenotransplantation as they share many
anatomical and physiological characteristics with humans. The most profound barrier to pig …

Hurdles exist to clinical xenotransplantation including potential infectious transmission from
nonhuman species to xenograft recipients. In anticipation of clinical trials of …

Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect
certain human cells and therefore pose a special risk for xenotransplantation using pig cells …

Porcine endogenous retroviruses (PERVs) represent a risk factor if porcine cells, tissues, or
organs were to be transplanted into human recipients to alleviate the shortage of human …