α-Synuclein in synaptic function and dysfunction
Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …
physiological conditions, it binds to synaptic vesicle membranes and functions in …
Toward dynamic structural biology: Two decades of single-molecule Förster resonance energy transfer
BACKGROUND Biomolecular mechanisms are typically inferred from static structural
“snapshots” obtained by x-ray crystallography, nuclear magnetic resonance (NMR) …
“snapshots” obtained by x-ray crystallography, nuclear magnetic resonance (NMR) …
The physiological role of α‐synuclein and its relationship to Parkinson's Disease
D Sulzer, RH Edwards - Journal of neurochemistry, 2019 - Wiley Online Library
The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …
In this review, we discuss recent results concerning its primary function, which appears to be …
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
Alterations in α-synuclein dosage lead to familial Parkinson's disease (PD), and its
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …
α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities
This review article provides an overview of the different species that α‐synuclein aggregates
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …
Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
Nucleophosmin (NPM1) is an abundant, oligomeric protein in the granular component of the
nucleolus with roles in ribosome biogenesis. Pentameric NPM1 undergoes liquid–liquid …
nucleolus with roles in ribosome biogenesis. Pentameric NPM1 undergoes liquid–liquid …
α-synuclein in the pathophysiology of Alzheimer's disease
D Twohig, HM Nielsen - Molecular neurodegeneration, 2019 - Springer
The Alzheimer's disease (AD) afflicted brain is neuropathologically defined by extracellular
amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of …
amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of …
Interactions between SARS-CoV-2 N-protein and α-synuclein accelerate amyloid formation
SA Semerdzhiev, MAA Fakhree… - ACS chemical …, 2021 - ACS Publications
First cases that point at a correlation between SARS-CoV-2 infections and the development
of Parkinson's disease (PD) have been reported. Currently, it is unclear if there is also a …
of Parkinson's disease (PD) have been reported. Currently, it is unclear if there is also a …
Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
Protein misfolding is a general hallmark of protein deposition diseases, such as Alzheimer's
disease or Parkinson's disease, in which different types of aggregated species (oligomers …
disease or Parkinson's disease, in which different types of aggregated species (oligomers …