As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as
an endocrine hormone that signals to distinct targets throughout the body. Interest in …

Fibroblast growth factor (FGF) 21 is a recently recognized metabolic regulator that evokes
interest due to its beneficial action of maintaining whole-body energy balance and protecting …

Background & Aims The ligand-activated transcription factor, aryl hydrocarbon receptor
(AHR) can sense xenobiotics, dietary, microbial, and metabolic cues. Roles of Ahr in …

The endocrine FGF21 was discovered as a novel metabolic regulator in 2005 with new
functions bifurcating from the canonic heparin-binding FGFs that directly promote cell …

Discovered almost simultaneously with insulin, glucagon is a pleiotropic hormone with
metabolic action that goes far beyond its classical role to increase blood glucose. Albeit best …

Metabolic dysfunction-associated steatohepatitis (MASH) is the progressive form of liver
steatosis, the most common liver disease, and substantially increases the mortality rate …

The gastrointestinal microbiome plays a significant role in modulating numerous host
processes, including metabolism. Prior studies show that when mice receive fecal …

Aims/hypothesis Glucagon receptor (GCGR) antagonism ameliorates hyperglycaemia and
promotes beta cell regeneration in mouse models of type 2 diabetes. However, the …

Background and Purpose Non‐alcoholic fatty liver disease (NAFLD) represents a severe
public health problem. It often coexists with hypertension in the context of metabolic …

A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the
host from resident and pathogenic microbiota through a mucus gel impregnated with …