Muscle strength is reduced during hypothermia, both in the presence and in the absence of
neuromuscular blocking drugs. A 2 degrees C reduction in body temperature may double …

Introduction Structure-function activity relationships of drugs that bind to certain membrane-
associated receptors must take into account the local membrane bilayer environment where …

Background Nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of
fast neurotransmitter-gated receptor channels that includes the gamma-aminobutyric acidA …

Nicotinic acetylcholine receptors are members of the ligand-gated ion channel superfamily,
that includes also gamma-amino-butiric-acidA, glycine, and 5-hydroxytryptamine3 receptors …

Background Astrocytes represent a major nonneuronal cell population in the central nervous
system (CNS) and are actively involved in several brain functions. These cells are coupled …

General anesthetics depress central nervous system excitability via a mechanism that
probably involves effects on synaptic ion channels, but the fundamental molecular nature of …

The mechanism and site (s) of action of volatile anesthetics are unknown. In all organisms
studied, volatile anesthetics adhere to the Meyer-Overton relationship--that is, a ln-ln plot of …

Background The site of action of general anesthesia remains controversial, but evidence in
favor of specific protein target (s) is accumulating. Saturable binding of halothane to bovine …

Awareness during anaesthesia is a state of consciousness that is revealed by explicit or
implicit memory of intraoperative events. Although large clinical surveys indicate an …

General anesthetics are a heterogeneous group of small amphiphilic ligands that interact
weakly at multiple allosteric sites on many pentameric ligand gated ion channels (pLGICs) …