Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy

KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …

Nanobodies: The potential application in bacterial treatment and diagnosis

S Yu, L Zhang, A Wang, Y Jin, D Zhou - Biochemical Pharmacology, 2023 - Elsevier
An infection caused by bacteria is one of the main factors that poses a threat to human
health. A recent report from the World Health Organization (WHO) has highlighted that …

Surface Plasmon Resonance Immunosensor for the Detection of Campylobacter jejuni

NA Masdor, Z Altintas, IE Tothill - Chemosensors, 2017 - mdpi.com
Campylobacteriosis is an internationally important foodborne disease caused by
Campylobacter jejuni. The bacterium is prevalent in chicken meat and it is estimated that as …

Recombinant antibodies for diagnostics and therapy against pathogens and toxins generated by phage display

P Kuhn, V Fühner, T Unkauf… - Proteomics–Clinical …, 2016 - Wiley Online Library
Antibodies are valuable molecules for the diagnostic and treatment of diseases caused by
pathogens and toxins. Traditionally, these antibodies are generated by hybridoma …

Advances in the production and batch reformatting of phage antibody libraries

RH Reader, RG Workman, BC Maddison… - Molecular …, 2019 - Springer
Phage display antibody libraries have proven an invaluable resource for the isolation of
diagnostic and potentially therapeutic antibodies, the latter usually being antibody fragments …

Subtractive inhibition assay for the detection of Campylobacter jejuni in chicken samples using surface plasmon resonance

NA Masdor, Z Altintas, MY Shukor, IE Tothill - Scientific Reports, 2019 - nature.com
In this work, a subtractive inhibition assay (SIA) based on surface plasmon resonance (SPR)
for the rapid detection of Campylobacter jejuni was developed. For this, rabbit polyclonal …

A Photoacoustic‐Fluorescent Imaging Probe for Proteolytic Gingipains Expressed by Porphyromonas gingivalis

C Moore, Y Cheng, N Tjokro, B Zhang… - Angewandte …, 2022 - Wiley Online Library
Porphyromonas gingivalis is a keystone pathogen in periodontal disease. We herein report
a dual‐modal fluorescent and photoacoustic imaging probe for the detection of gingipain …

An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase

S Odongo, YGJ Sterckx, B Stijlemans… - PLoS neglected …, 2016 - journals.plos.org
Background Infectious diseases pose a severe worldwide threat to human and livestock
health. While early diagnosis could enable prompt preventive interventions, the majority of …

Natural single-domain antibody-nanobody: a novel concept in the antibody field

C Li, Z Tang, Z Hu, Y Wang, X Yang… - Journal of Biomedical …, 2018 - ingentaconnect.com
Since the serendipitous discovery of heavy-chain antibodies in Camelidae 20 years ago, the
smallest single-domain antigen-binding fragment, known as VHH or nanobody, has …

Nanobodies in human infections: prevention, detection, and treatment

M Sanaei, N Setayesh, Z Sepehrizadeh… - Immunological …, 2020 - Taylor & Francis
Despite the existence of vaccination, antibiotic therapy, and antibody therapies, infectious
diseases still remain as one of the biggest challenges to human health all over the world …