Imprinted genes and the manipulation of parenting in mammals

RM John, MJ Higgs, AR Isles - Nature Reviews Genetics, 2023 - nature.com
Genomic imprinting refers to the parent-of-origin expression of genes, which originates from
epigenetic events in the mammalian germ line. The evolution of imprinting may reflect a …

Cellular interactions in the pituitary stem cell niche

TL Willis, EJ Lodge, CL Andoniadou… - Cellular and Molecular Life …, 2022 - Springer
Stem cells in the anterior pituitary gland can give rise to all resident endocrine cells and are
integral components for the appropriate development and subsequent maintenance of the …

Organizational effects of estrogens and androgens on estrogen and androgen receptor expression in pituitary and adrenal glands in adult male and female rats

N Lagunas, JM Fernández-García, N Blanco… - Frontiers in …, 2022 - frontiersin.org
Sex steroid hormones, such as androgens and estrogens, are known to exert organizational
action at perinatal periods and activational effects during adulthood on the brain and …

[HTML][HTML] Exploring the Role of the TAS2R16 Protein and Its Single Nucleotide Variants in Pituitary Adenoma Development

E Pileckaite, A Vilkeviciute… - Biomedicines, 2024 - mdpi.com
Background: Pituitary adenoma (PA) is a common benign tumor that develops in the pituitary
gland, causing hormonal imbalances and potential health issues. The TAS2R16 gene codes …

Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution

MJ Higgs, MJ Hill, RM John, AR Isles - BMC genomics, 2022 - Springer
Background Although a number of imprinted genes are known to be highly expressed in the
brain, and in certain brain regions in particular, whether they are truly over-represented in …

Long Noncoding RNAs Expressed in Mouse Pituitary Development and Mature Hormone-Producing Cells

ML Brinkmeier, AS George, LYM Cheung… - …, 2024 - academic.oup.com
Mammalian genomes contain thousands of genes for long noncoding RNA (lncRNAs), some
of which have been shown to affect protein coding gene expression through diverse …

Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland

V Scagliotti, ML Vignola, T Willis, M Howard, E Marinelli… - Elife, 2023 - elifesciences.org
Co-regulated genes of the Imprinted Gene Network are involved in the control of growth and
body size, and imprinted gene dysfunction underlies human paediatric disorders involving …

[HTML][HTML] Integrating Transcriptomics, Proteomics, and Metabolomics to Investigate the Mechanism of Fetal Placental Overgrowth in Somatic Cell Nuclear Transfer …

X Zhao, S Wu, Y Yun, Z Du, S Liu, C Bo, Y Gao… - International Journal of …, 2024 - mdpi.com
A major factor limiting the development of somatic cell nuclear transfer (SCNT) technology is
the low success rate of pregnancy, mainly due to placental abnormalities disrupting the …

[HTML][HTML] 表观遗传学调控雌性动物初情期启动的研究进展

张为, 潘志豪, 方富贵 - 畜牧兽医学报, 2024 - html.rhhz.net
雌性动物初情期是指第一次出现发情表现并排卵的时期. 初情期启动机制复杂, 与遗传,
神经内分泌, 代谢, 营养和环境等因素密切相关. 但动物初情期启动的具体机制仍不明确 …

[PDF][PDF] KLF14PDE10A基因的印记鉴定和甲基化分析

董艳秋, 靳兰杰, 杨欣怡, 李冬杰, 霍浩楠… - 农业生物技术 …, 2023 - journal05.magtech.org.cn
摘要在哺乳动物中, 印记基因与胎盘发育和胎儿生长密切相关. 印记基因的表达变化会通过各种
生理反应和信号通路导致哺乳动物生长发育异常并引发相关疾病. KLF14 (Kruppel like factor …