Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …

Disrupted operations of the reward circuit underlie major emotional disorders, including
depression, which commonly arise following early life stress/adversity (ELA). However, how …

Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …

Fibromyalgia is characterized by widespread pain, fatigue, sleep disturbances and other
symptoms, and has a substantial socioeconomic impact. Current biomedical and …

Early-life stress (ELS) is associated with increased vulnerability to mental disorders. The
basolateral amygdala (BLA) plays a critical role in fear conditioning and is extremely …

Background Adverse childhood experiences have been linked to increased multimorbidity,
with physical and mental health consequences throughout life. Chronic pain is often …

Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia
has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail …

The neurobiology and development of treatments for stress-related neuropsychiatric
disorders rely heavily on animal models. However, the complexity of these disorders makes …