Over the past 50 years in the field of immunology, something of a Copernican revolution has
happened. For a long time, immunologists were mainly concerned with what is termed …

The intestinal microbiome harbors fungi that pose a significant risk to human health as
opportunistic pathogens and drivers of inflammation. Inflammatory and autoimmune …

Citrobacter rodentium models infection with enteropathogenic Escherichia coli and
ulcerative colitis (UC). While C57BL/6 (C57) mice recover, C3H/HeN (C3H) mice succumb to …

The gut microbiota has emerged as an environmental risk factor that affects thrombotic
phenotypes in several cardiovascular diseases. Evidence includes the identification of …

The complement system is an evolutionarily conserved arm of innate immunity, which forms
one of the first lines of host response to pathogens, and assists in the clearance of debris. A …

Arteriogenesis is an inflammatory driven mechanism, describing the growth of a natural
bypass from pre-existing collateral arteries to compensate for an occluded artery. The …

Complement, traditionally perceived as a liver-derived and plasma-operative guardian
against bloodborne pathogens, is increasingly recognized as a local and central player in …

Complement proteins form a proteolytic cascade to clear invading microbes. In a recent
issue of Cell, Wu et al. and Xu et al. demonstrate two distinct complement systems operating …

Infections are one of the most significant healthcare and economic burdens across the world
as underscored by the recent coronavirus pandemic. Moreover, with the increasing …

Therapeutic recombinant proteins are powerful tools used for the treatment of many
detrimental diseases such as diabetes, cancer, multiple sclerosis, rheumatoid arthritis …