Two-component systems required for virulence in Pseudomonas aeruginosa

VI Francis, EC Stevenson, SL Porter - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad
range of hosts, in addition to thriving in a broad range of environmental conditions outside of …

[HTML][HTML] Recent advances in understanding Pseudomonas aeruginosa as a pathogen

J Klockgether, B Tümmler - F1000Research, 2017 - ncbi.nlm.nih.gov
The versatile and ubiquitous Pseudomonas aeruginosa is an opportunistic pathogen
causing acute and chronic infections in predisposed human subjects. Here we review recent …

Matrix exopolysaccharides; the sticky side of biofilm formation

E Maunders, M Welch - FEMS microbiology letters, 2017 - academic.oup.com
Abstract The Gram-negative pathogen Pseudomonas aeruginosa is found ubiquitously
within the environment and is recognised as an opportunistic human pathogen that …

Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection

DH Limoli, GB Whitfield, T Kitao, ML Ivey, MR Davis Jr… - MBio, 2017 - Am Soc Microbiol
While complex intra-and interspecies microbial community dynamics are apparent during
chronic infections and likely alter patient health outcomes, our understanding of these …

Electron-shuttling antibiotics structure bacterial communities by modulating cellular levels of c-di-GMP

C Okegbe, BL Fields, SJ Cole… - Proceedings of the …, 2017 - National Acad Sciences
Diverse organisms secrete redox-active antibiotics, which can be used as extracellular
electron shuttles by resistant microbes. Shuttle-mediated metabolism can support survival …

Molecular and structural facets of c-di-GMP signalling associated with biofilm formation in Pseudomonas aeruginosa

P Banerjee, PK Sahoo, A Adhikary, R Ruhal… - Molecular Aspects of …, 2021 - Elsevier
Pseudomonas aeruginosa is an opportunistic human pathogen and is the primary cause of
nosocomial infections. Biofilm formation by this organism results in chronic and hard to …

Mechanisms of Virulence Reprogramming in Bacterial Pathogens

J Zhou, H Ma, L Zhang - Annual Review of Microbiology, 2023 - annualreviews.org
Bacteria are single-celled organisms that carry a comparatively small set of genetic
information, typically consisting of a few thousand genes that can be selectively activated or …

Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa

G Chen, J Zhou, Y Zuo, W Huo, J Peng, M Li, Y Zhang… - Elife, 2021 - elifesciences.org
Cyclic-di-guanosine monophosphate (c-di-GMP) is an important effector associated with
acute-chronic infection transition in Pseudomonas aeruginosa. Previously, we reported a …

Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme

DC Patterson, MP Ruiz, H Yoon… - Proceedings of the …, 2021 - National Acad Sciences
Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a second messenger that
modulates bacterial cellular processes, including biofilm formation. While proteins …

The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa

G Chen, J Gan, C Yang, Y Zuo, J Peng, M Li… - The EMBO …, 2020 - embopress.org
Bacterial cyclic‐di‐GMP (c‐di‐GMP) production is associated with biofilm development and
the switch from acute to chronic infections. In Pseudomonas aeruginosa, the diguanylate …