Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

Cancer, one of major threats to the human health, possesses intricate structure and
constituents distinctive from normal organs and tissues. It has been well recognized that the …

Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …

New therapeutic strategies have emerged along with our understanding that disturbances of
iron homeostasis, impaired proliferation of erythroid progenitor cells, and blunted …

Cancer-related anemia (CRA) is a common sign occurring in more than 30% of cancer
patients at diagnosis before the initiation of antineoplastic therapy. CRA has a relevant …

The European Cancer Anaemia Survey (ECAS) was conducted to prospectively evaluate
the prevalence, incidence and treatment of anaemia (haemoglobin< 12.0 g/dL) in European …

BACKGROUND Anemia is common in cancer patients, although the prevalence is
influenced both by the type of malignancy and the choice of treatment. Individual studies …

Oxidative stress is a key component in linking environmental toxicity to the multistage
carcinogenic process. Reactive oxygen species (ROS) are generated in response to both …

Background The National Cancer Institute (USA) alert in February 1999 stated that
concomitant chemoradiotherapy should be considered for all patients with cervical cancer …

Hypoxic areas are a characteristic property of solid tumors. Hypoxia results from an
imbalance between the supply and consumption of oxygen. Major pathogenetic …