Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

Persisters are dormant variants of regular cells that form stochastically in microbial
populations and are highly tolerant to antibiotics. High persister (hip) mutants of …

Persisters are dormant phenotypic variants of bacterial cells that are tolerant to killing by
antibiotics 1. Persisters are associated with chronic infections and antibiotic treatment failure …

All bacteria form persisters, cells that are multidrug tolerant and therefore able to survive
antibiotic treatment. Due to the low frequencies of persisters in growing bacterial cultures …

Chronic infections are difficult to treat with antibiotics but are caused primarily by drug-
sensitive pathogens. Dormant persister cells that are tolerant to killing by antibiotics are …

Biofilms contain bacterial cells that are in a wide range of physiological states. Within a
biofilm population, cells with diverse genotypes and phenotypes that express distinct …

The majority of cystic fibrosis (CF) patients succumb to a chronic infection of the airway with
Pseudomonas aeruginosa. Paradoxically, pathogenic strains are often susceptible to …

Bacteria induce stress responses that protect the cell from lethal factors such as DNA-
damaging agents. Bacterial populations also form persisters, dormant cells that are highly …

Several well-recognized puzzles in microbiology have remained unsolved for decades.
These include latent bacterial infections, unculturable microorganisms, persister cells and …

HipA of Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth
and induces persistence (multidrug tolerance). Previously, it was proposed that HipA inhibits …