[HTML][HTML] Microbial genetic engineering approach to replace shark livering for squalene

A Patel, M Bettiga, U Rova, P Christakopoulos… - Trends in …, 2022 - cell.com
Squalene is generally sourced from the liver oil of deep sea sharks (Squalus spp.), in which
it accounts for 40–70% of liver mass. To meet the growing demand for squalene because of …

[HTML][HTML] Recent advances in the microbial production of squalene

K Paramasivan, S Mutturi - World Journal of Microbiology and …, 2022 - Springer
Squalene is a triterpene hydrocarbon, a biochemical precursor for all steroids in plants and
animals. It is a principal component of human surface lipids, in particular of sebum …

Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in Yarrowia lipolytica

Y Ma, Y Shang… - Proceedings of the …, 2024 - National Acad Sciences
Constructing efficient cell factories for product synthesis is frequently hampered by
competing pathways and/or insufficient precursor supply. This is particularly evident in the …

Metabolic compartmentalization in yeast mitochondria: Burden and solution for squalene overproduction

ZT Zhu, MM Du, B Gao, XY Tao, M Zhao, YH Ren… - Metabolic …, 2021 - Elsevier
Harnessing mitochondria is considered as a promising method for biosynthesis of terpenes
due to the adequate supply of acetyl-CoA and redox equivalents in mitochondria. However …

[HTML][HTML] Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions

KJ Fisher, R Kinsey, R Mohamath, T Phan, H Liang… - npj Vaccines, 2023 - nature.com
Synthetic biology has allowed for the industrial production of supply-limited
sesquiterpenoids such as the antimalarial drug artemisinin and β-farnesene. One of the only …

[HTML][HTML] Practical Considerations for Next-Generation Adjuvant Development and Translation

WR Lykins, CB Fox - Pharmaceutics, 2023 - mdpi.com
Over the last several years, there has been increased interest from academia and the
pharmaceutical/biotech industry in the development of vaccine adjuvants for new and …

[HTML][HTML] Sustainable biosynthesis of squalene from waste cooking oil by the yeast Yarrowia lipolytica

S Wang, X Sun, Y Han, Z Li, X Lu, H Shi… - Metabolic Engineering …, 2024 - Elsevier
Squalene is a highly sought-after triterpene compound in growing demand, and its
production offers a promising avenue for circular economy practices. In this study, we …

Efficacy of nutraceuticals (probiotics or prebiotics or synbiotics) in the prevention or treatment of COVID-19: a systematic review and meta-analysis

AP Sinha, MN Khatib, A Gaidhane… - Cogent Food & …, 2024 - Taylor & Francis
Nutraceuticals have generated an interest among clinicians for their applicability in the
prevention and treatment of many ailments. Literature suggests the possible role of …

[HTML][HTML] Preclinical study of immunogenicity of adjuvanted quadrivalent subunit influenza vaccine

IV Krasilnikov, AV Ivanov, AM Nikolaeva… - Journal of …, 2022 - microbiol.crie.ru
Background. Preventive vaccination is a vitally important strategic aspect of protection of the
population against severe effects of influenza epidemics. The priority attention is given to …

Valorization of Seafood Processing By‐Products for Bioactive Compounds

PV Suresh, AR Brundha, TG Kudre… - Nutraceutics from Agri …, 2025 - Wiley Online Library
Seafood is one of the major commodities contributing to global food security. Global seafood
production was about 177.8 million tons in 2019, with a total first sale value equivalent to US …