[HTML][HTML] Allopregnanolone in postpartum depression: Role in pathophysiology and treatment

S Meltzer-Brody, SJ Kanes - Neurobiology of stress, 2020 - Elsevier
Postpartum depression (PPD) is a unique subtype of major depressive disorder and a
substantial contributor to maternal morbidity and mortality. In addition to affecting the mother …

Advances in the treatment of chronic insomnia: a narrative review of new nonpharmacologic and pharmacologic therapies

R Rosenberg, L Citrome, CL Drake - Neuropsychiatric Disease and …, 2021 - Taylor & Francis
Chronic insomnia disorder, which affects 6–10% of the population, is diagnostically
characterized by ongoing difficulties with initiating or maintaining sleep occurring at least …

Herbal remedies and their possible effect on the GABAergic system and sleep

O Bruni, L Ferini-Strambi, E Giacomoni, P Pellegrino - Nutrients, 2021 - mdpi.com
Sleep is an essential component of physical and emotional well-being, and lack, or
disruption, of sleep due to insomnia is a highly prevalent problem. The interest in …

Sleep physiology, circadian rhythms, waking performance and the development of sleep-wake therapeutics

DJ Dijk, HP Landolt - Sleep-wake neurobiology and pharmacology, 2019 - Springer
Disturbances of the sleep-wake cycle are highly prevalent and diverse. The aetiology of
some sleep disorders, such as circadian rhythm sleep-wake disorders, is understood at the …

Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases

ST Foliaki, B Schwarz, BR Groveman, RO Walters… - Molecular brain, 2021 - Springer
The neuro-physiological properties of individuals with genetic pre-disposition to
neurological disorders are largely unknown. Here we aimed to explore these properties …

Excitatory pathways from the lateral habenula enable propofol-induced sedation

C Gelegen, G Miracca, MZ Ran, EC Harding, Z Ye… - Current Biology, 2018 - cell.com
The lateral habenula has been widely studied for its contribution in generating reward-
related behaviors [1, 2]. We have found that this nucleus plays an unexpected role in the …

Neuroprotective effect of Ziziphi Spinosae Semen on rats with p-chlorophenylalanine-induced insomnia via activation of GABAA receptor

F Xiao, S Shao, H Zhang, G Li, S Piao… - Frontiers in …, 2022 - frontiersin.org
Ziziphus jujuba var. spinosa (Bunge) Hu ex HF. Chow [Rhamnaceae; Ziziphi Spinosae
Semen (ZSS)] has attracted extensive attention as the first choice of traditional Chinese …

[HTML][HTML] Heukharang lettuce (Lactuca sativa L.) leaf extract displays sleep-promoting effects through GABAA receptor

Y Ahn, HH Lee, BH Kim, SJ Park, YS Kim… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Although lettuce is traditionally known to have hypnotic
and sedative effects, to date, only a few studies have documented its sleep-promoting effects …

Understanding the mechanisms of action and effects of drugs of abuse

DM Ciucă Anghel, GV Nițescu, AT Tiron, CM Guțu… - Molecules, 2023 - mdpi.com
Aim. Drug abuse and addiction are major public health concerns, with millions of people
worldwide affected by the negative consequences of drug use. To better understand this …

Understanding the function of the GABAergic system and its potential role in rheumatoid arthritis

Y Shan, J Zhao, Y Zheng, S Guo, SJ Schrodi… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a highly disabling chronic autoimmune disease. Multiple factors
contribute to the complex pathological process of RA, in which an abnormal autoimmune …