Considerable ingenuity has been shown in the recent years in the discovery of novel
xanthine oxidase (XO) inhibitors that fall outside the purine scaffold. The triazole nucleus …

Compounds containing the 1, 2, 4-triazole moiety in their structure exhibit broad biological
activities. Many of these compounds demonstrate anti-inflammatory activity in vitro through …

(1) Background: Callerya atropurpurea is found in Laos, Thailand, and Vietnam. Although
the anti-inflammatory action of C. atropurpurea has been investigated, the functions of this …

Inflammation is a multifaceted phenomenon triggered by potentially active mediators acutely
released arachidonic acid metabolites partially in lipoxygenase (LOX) pathway which are …

Grewia tomentosa Juss. is a deciduous shrub that mainly grows in Asia. Despite studies of
other Grewia species for treatment of various diseases, Grewia tomentosa Juss. has not …

In the present work, new Naproxen based 1, 2, 4-triazole-Schiff base derivatives have been
synthesized and screened for in vitro antitumor activity and in silico pharmacokinetic studies …

In this paper, we attempted to develop a novel class of compounds against lipoxygenase, a
key enzyme in the biosynthesis of leukotrienes implicated in a series of inflammatory …

Inflammation is an intricate process exacerbated by the sequential release of lipid mediators
during arachidonic acid metabolism through the LOX and COX pathways. The inhibition of …

The diverse biological activities of 1, 3, 4-oxadiazole derivatives are very significant due to
structural complexity. Concentrating on metal free synthesis of 1, 3, 4-oxadiazole hybrids, 5a …

One of the triazole tautomers, 1, 2, 4‐triazole derivatives, has a wide range of biological
activities that suggest its potential therapeutic utility in medicinal chemistry. These actions …