Hydrogen-atom transfer mediated by earth-abundant transition-metal hydrides (M-Hs) has
emerged as a powerful tool in organic synthesis. Current methods to generate M-Hs most …

Conspectus Natural product research originates from a desire to explore, understand, and
perturb biological function with atomic precision. To reach these goals at all, let alone …

Metal-hydride hydrogen atom transfer (MHAT) has emerged as a useful tool to form
quaternary carbons from alkenes via hydrofunctionalization. Methods to date that cross …

Oxidative MHAT hydrofunctionalization of alkenes provides a mild cobalt-catalyzed route to
forming C–N and C–O bonds. Here, we characterize relevant salen-supported cobalt …

The catalytic hydrofunctionalization of alkenes through radical-polar crossover metal
hydrogen atom transfer (MHAT) offers a mild pathway for the introduction of functional …

We disclose a general electrocatalytic hydroetherification for modular synthesis of alkyl aryl
ethers by utilizing a wide range of alkenes and phenols. The integration of the two involves …

Catalytic Markovnikov-selective hydroamination of unactivated alkenes, in particular by
using secondary amines as nucleophiles and/or in an intermolecular setting, remains a …

This study demonstrates the efficient synthesis of various heterocycles using the metal
hydrogen atom transfer (MHAT)/radical-polar crossover (RPC) method, emphasizing its …

Chapter 1 describes the field of metal-mediated hydrogen atom transfer (MHAT) reactions.
An overview of synthetic methods which use MHAT is discussed. Two classes of metal …