As our understanding of cancer cell biology progresses, it has become clear that tumors are
a heterogenous mixture of different cell populations, some of which contain so called …

Glioblastomas (glioblastoma multiforme, GBM) are one of the most recalcitrant brain tumors
because of their aggressive invasive growth and resistance to therapy. They are highly …

High-grade gliomas are rapidly progressing tumors of the central nervous system (CNS) with
a very poor prognosis despite extensive resection combined with radiation and/or …

Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer due to its highly
invasive nature that impedes the surgical removal of all tumor cells, making relapse …

Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-
related protein produced in the periosteum and periodontal ligaments. Matricellular proteins …

Integrins are a large family of transmembrane adhesion receptors, which play a key role in
interactions of a cell with the surrounding stroma. Integrins are comprised of non-covalently …

Sex differences in human health and disease can range from undetectable to profound.
Differences in brain tumor rates and outcome are evident in males and females throughout …

Periostin is a matricellular protein that has been implicated in many disease states. It
interacts with multiple signaling cascades to modulate the expression of downstream genes …

The epithelial‐to mesenchymal (EMT) process is increasingly recognized for playing a key
role in the progression, dissemination, and therapy resistance of epithelial tumors …

Imaging diagnosis is crucial for early detection and monitoring of brain tumors. Radiomics
enable the extraction of a large mass of quantitative features from complex clinical imaging …