Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

A wide spectrum of clinical manifestations has become a hallmark of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although the …

Severe SARS-CoV-2 infection has been associated with highly inflammatory immune
activation since the earliest days of the COVID-19 pandemic,,–. More recently, these …

Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

B lymphocytes have a central role in autoimmune diseases, which are often defined by
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …

The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …

The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …

The upper airway is an important site of infection, but immune memory in the human upper
airway is poorly understood, with implications for COVID-19 and many other human …