Histology permits the observation of otherwise invisible structures of the internal topography
of a specimen. Although it enables the investigation of tissues at a cellular level, it is invasive …

Histology and immunohistochemistry of thin tissue sections have been the standard
diagnostic procedure in many diseases for decades. This method is highly specific for …

To quantitatively evaluate brain tissue and its corresponding function, knowledge of the 3D
cellular distribution is essential. The gold standard to obtain this information is histology, a …

Historically, micro-computed tomography (μCT) has been considered unsuitable for
histologic analysis of unstained formalin-fixed, paraffin-embedded soft tissue biopsy …

There have been great efforts on the nanoscale 3D probing of brain tissues to image
subcellular morphologies. However, limitations in terms of tissue coverage, anisotropic …

A multiscale three-dimensional (3D) virtual histology approach is presented, based on two
configurations of propagation phase-contrast X-ray tomography, which have been …

Background: Micrometer-resolution neuroimaging with gold-standard conventional histology
requires tissue fixation and embedding. The exchange of solvents for the creation of …

Abstract Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disorder associated with aberrant production of beta-amyloid (Aβ) …

We present a three-dimensional (3D) approach for virtual histology and histopathology
based on multi-scale phase contrast x-ray tomography, and use this to investigate the …

Objectives. As the central organ of the respiratory system, the human lung is responsible for
supplying oxygen to the blood, which reaches the erythrocytes by diffusion through the …