Thioredoxin-interacting protein in cancer and diabetes

H Masutani - Antioxidants & Redox Signaling, 2022 - liebertpub.com
Significance: Thioredoxin-interacting protein (Txnip) is an α-arrestin protein that acts as a
cancer suppressor. Txnip is simultaneously a critical regulator of energy metabolism. Other …

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma

K Rindler, C Jonak, N Alkon, FM Thaler, H Kurz… - Molecular cancer, 2021 - Springer
Background In early-stage mycosis fungoides (MF), the most common primary cutaneous T-
cell lymphoma, limited skin involvement with patches and plaques is associated with a …

Expanding the armory for treating lymphoma: Targeting redox cellular status through thioredoxin reductase inhibition

S Wang, G Di Trapani, KF Tonissen - Pharmacological Research, 2022 - Elsevier
Lymphoma refers to a group of cancers that arise from lymphocytes and is the most common
form of hematological malignancy in adults. While the recent availability of specific …

Fluoxetine increases astrocytic glucose uptake and glycolysis in corticosterone-induced depression through restricting GR-TXNIP-GLUT1 Pathway

SM Pan, YF Zhou, N Zuo, RQ Jiao, LD Kong… - Frontiers in …, 2022 - frontiersin.org
Antidepressant fluoxetine can affect cerebral glucose metabolism in clinic, but the
underlying molecular mechanism remains poorly understood. Here, we examined the effect …

Differential requirements for different subfamilies of the mammalian SWI/SNF chromatin remodeling enzymes in myoblast cell cycle progression and expression of the …

T Padilla-Benavides, M Olea-Flores, Y Nshanji… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Abstract The mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) families of ATP-
dependent chromatin remodeling enzymes are established co-regulators of gene …

Txnip deficiency promotes β-cell proliferation in the HFD-induced obesity mouse model

Z Lei, Y Chen, J Wang, Y Zhang, W Shi… - Endocrine …, 2022 - ec.bioscientifica.com
Elucidating the mechanisms of regulation of β cell proliferation is key to understanding the
pathogenesis of diabetes mellitus. Txnip is a tumor suppressor that is upregulated in …

RETRACTED ARTICLE: Tumor-derived exosomal microRNA-15b-5p augments laryngeal cancer by targeting TXNIP

F Yu, Y Lin, G Tan, M Ai, H Gong, W Liu, J Huang… - Cell Cycle, 2022 - Taylor & Francis
Statement of Retraction We, the Editors and Publisher of the journal Cell Cycle, have
retracted the following article: Feng Yu, Ying Lin, Guojie Tan, Maomao Ai, Huicheng Gong …

Phenotypic plasticity of malignant T cells in blood and skin of a Sézary syndrome patient revealed by single cell transcriptomics

L Peiffer, T Gambichler, TB Buus, K Horny… - Frontiers in …, 2023 - frontiersin.org
Background Sézary Syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell
lymphomas (CTCL). In SS patients, malignant T cells are circulating through the blood and …

[PDF][PDF] downloaded from the King's Research Portal at https://kclpure. kcl. ac. uk/portal

J Deng - 2023 - kclpure.kcl.ac.uk
Colorectal cancer is the fourth most lethal cancer worldwide. Conventional cytotoxic
chemotherapy is the standard of care treatment for patients with advanced disease. The …

EPIGENETIC REGULATION OF THE POTENTIAL TUMOR SUPPRESSOR TXNIP

J Gutiérrez-Pajares - Revista Científica en Ciencias de la Salud, 2022 - csalud.unat.edu.pe
Las células cancerosas adquieren importantes características que les permiten adaptarse a
diferentes microambientes y proliferar indefinidamente. Con esa finalidad, se orquestan …