Traditional therapeutic approaches such as chemotherapy and radiation therapy have
burdened cancer patients with onerous physical and psychological challenges …

RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …

In 2015, oncolytic virotherapy was approved for clinical use, and in 2017, recombinant
adeno-associated virus (AAV) delivery was also approved. However, systemic …

Background Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes
oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. With the …

Oncolytic virus (OV) therapy has been shown to be an effective targeted cancer therapy
treatment in recent years, providing an avenue of treatment that poses no damage to …

Background The attenuated, genetically engineered vaccinia virus has been shown to be a
promising oncolytic virus for the treatment of patients with solid tumors, through both direct …

Colorectal cancer is one of the most common causes of mortality worldwide. There are
several potential risk factors responsible for the initiation and progression of colorectal …

Alongside the conventional methods, attention has been drawn to the use of immunotherapy-
based methods for cancer treatment. Immunotherapy has developed as a therapeutic option …

Soft tissue sarcomas (STS) are diverse mesenchymal tumors with few therapeutic options in
advanced stages. Trabectedin has global approval for treating STS patients resistant to …

Tumor immunotherapy, especially immune checkpoint inhibitors (ICIs), has been applied in
clinical practice, but low response to immune therapies remains a thorny issue. Oncolytic …