Wnt/β‐catenin signalling is known to play many roles in metazoan development and tissue
homeostasis. Misregulation of the pathway has also been linked to many human diseases …

A variety of studies that are currently underway may validate the fruit fly as an in vivo model
for analyzing genes involved in cardiac function. Many mutations in conserved genetic …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

The specification of neuronal fates in the ventral spinal cord depends on the regulation of
homeodomain (HD) and basic-helix-loop-helix (bHLH) proteins by Sonic hedgehog (Shh) …

The gene expression pattern specified by an animal regulatory sequence is generally
viewed as arising from the particular arrangement of transcription factor binding sites it …

The existence of hemangioblasts, which serve as common progenitors for hematopoietic
cells and cardioblasts, has suggested a molecular link between cardiogenesis and …

Nervous system-specific eve mutants were created by removing regulatory elements from a
16 kb transgene capable of complete rescue of normal eve function. When transgenes …

The Hand gene family encodes highly conserved basic helix-loop-helix (bHLH) transcription
factors that play crucial roles in cardiac and vascular development in vertebrates. In …

Cardiac induction in Drosophila relies on combinatorial Dpp and Wg signaling activities that
are derived from the ectoderm. Although some of the actions of Dpp during this process …

Unraveling the gene regulatory networks that govern development and function of the
mammalian heart is critical for the rational design of therapeutic interventions in human …