The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …

Human newborns and infants are bombarded with multiple pathogens on leaving the sterile
intra-uterine environment, and yet have suboptimal innate immunity and limited …

Immune nonresponder (INR) HIV-1–infected subjects are characterized by their inability to
reconstitute the CD4+ T cell pool after antiretroviral therapy. This is linked to poor clinical …

To obtain a comprehensive scenario of T cell profiles and synergistic immune responses, we
performed single-cell RNA sequencing (scRNA-seq) on the peripheral T cells of 14 …

Treg and Th17 cell subsets are characterized by the expression of specific transcriptional
factors and chemokine receptor as well as by secretion of specific cytokine and chemokines …

Background: Terms and criteria to classify people living with HIV on antiretroviral therapy
who fail to achieve satisfactory CD4+ T-cell counts are heterogeneous, and need revision …

The intestinal epithelial barrier plays an important role during human immunodeficiency
virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier …

The goal of antiretroviral treatment (ART) in HIV-1 patients is immune reconstitution
following control of viral replication. CD4+ cell number/proportions are a crude but essential …

Objective: To explore immune mechanisms and identify biomarkers associated with an
inadequate immune recovery in patients with HIV with efficient antiretroviral therapy. Design …

Background: HIV infection is associated with increased ratio between kynurenine and
tryptophan (KTR) in plasma, increased microbial translocation, expansion of regulatory T …