RNA interference mediated inhibition of adenosine A1 receptor (ADORA1) gene expression using short interfering RNA
K Fosnaugh, J McSwiggen - US Patent App. 10/224,005, 2003 - Google Patents
Correspondence Address: MCDONNELL BOEHNEN HULBERT &(57) ABSTRACT
BERGHOFF The present invention concerns methods and reagents useful 300 SOUTH …
BERGHOFF The present invention concerns methods and reagents useful 300 SOUTH …
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
J McSwiggen, L Beigelman - US Patent 8,202,979, 2012 - Google Patents
2004-09-27 Assigned to SIRNA THERAPEUTICS, INC. reassignment SIRNA
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
Interfering RNA molecules
K Giese, J Kaufmann, A Klippel-Giese - US Patent 7,452,987, 2008 - Google Patents
The present invention is related to a ribonucleic acid com prising a double stranded
structure whereby the double Stranded structure comprises a first strand and a second …
structure whereby the double Stranded structure comprises a first strand and a second …
Conjugates and compositions for cellular delivery
C Vargeese, P Haeberli, W Wang, T Chen - US Patent 7,491,805, 2009 - Google Patents
0* CC (CC ([12*]) C) N ([8*]) C (= O) CCN ([3*]) C (= O) CCC (C) N ([5*]) C (= O) C1= CC= C
(N ([6*]) CC2= NC3= C (N= C2) N= C (C) NC3= O) C= C1 Chemical compound* CC (CC …
(N ([6*]) CC2= NC3= C (N= C2) N= C (C) NC3= O) C= C1 Chemical compound* CC (CC …
Conjugates and compositions for cellular delivery
C Vargeese, P Haeberli, W Wang, T Chen - US Patent 7,833,992, 2010 - Google Patents
US7833992B2 - Conjugates and compositions for cellular delivery - Google Patents
US7833992B2 - Conjugates and compositions for cellular delivery - Google Patents Conjugates …
US7833992B2 - Conjugates and compositions for cellular delivery - Google Patents Conjugates …
System for targeted delivery of therapeutic agents
5,503,627 A 4/1996 McKinnon etal. 6,399,754 B1 6/2002 C001< _ 5,512,600 A 4/1996
M1kose1a1. 6,403,779 B1 6/2002 Kawasakl et al. 5,514,378 A 5/1996 M1koseta1 …
M1kose1a1. 6,403,779 B1 6/2002 Kawasakl et al. 5,514,378 A 5/1996 M1koseta1 …
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
J McSwiggen, D Macejak, D Morrissey - US Patent App. 10/826,966, 2005 - Google Patents
MRBUKYZHZWTXMC-UHFFFAOYSA-N C. CC (C) N (C (C) C) C (C) C. CC (C) N (C) C. CC
(C) N1CCCC1. CC (C) N1CCOCC1. CCN (CC) C (C) C Chemical compound C. CC (C) N (C …
(C) N1CCCC1. CC (C) N1CCOCC1. CCN (CC) C (C) C Chemical compound C. CC (C) N (C …
Modified polynucleotides for reducing off-target effects in RNA interference
D Leake, A Reynolds, A Khvorova, W Marshall… - US Patent …, 2009 - Google Patents
Methods and compositions for performing RNA interference with decreased off-target effects
are provided The methods and compositions permit effective and efficient applications of …
are provided The methods and compositions permit effective and efficient applications of …
Oligoribonucleotides and ribonucleases for cleaving RNA
ST Crooke - US Patent 7,695,902, 2010 - Google Patents
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
J McSwiggen, L Beigelman - US Patent 7,923,547, 2011 - Google Patents
2008-06-19 Assigned to SIRNA THERAPEUTICS, INC. reassignment SIRNA
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …