Mitogen-activated protein kinase (MAPK) cascades are key signaling pathways involved in
the regulation of normal cell proliferation, survival and differentiation. Aberrant regulation of …

It is now accepted that the growth of solid tumours is dependent on their capacity to acquire
a blood supply, and much effort has been directed towards the development of agents …

▪ Abstract Anthrax toxin consists of three nontoxic proteins that associate in binary or ternary
combinations to form toxic complexes at the surface of mammalian cells. One of these …

The bacterium Bacillus anthracis causes the death of macrophages, which may allow it to
avoid detection by the innate immune system. We found that B. anthracis lethal factor (LF) …

Hepatocyte growth factor/scatter factor (HGF/SF), acting through the Met receptor, plays an
important role in most human solid tumors, and inappropriate expression of this ligand …

Lethal factor (LF) is a protein (relative molecular mass 90,000) that is critical in the
pathogenesis of anthrax,,. It is a highly specific protease that cleaves members of the …

Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and
can replicate the lethality and symptoms associated with the disease. This review provides …

The mitogen-activated protein kinase (MAPK) signaling pathways play essential roles in cell
proliferation and differentiation. Recent studies also show the activation of MAPK signaling …

Tumor endothelial marker (TEM) 8 was uncovered as a gene expressed predominantly in
tumor endothelium, and its protein product was recently identified as the receptor for anthrax …

Anthrax toxin, a major virulence factor of Bacillus anthracis, gains entry into target cells by
binding to either of 2 von Willebrand factor A domain-containing proteins, tumor endothelium …