Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in
patterns of gene expression and developmental potential as they progress from pre …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency
continuum in vivo. Previous studies have generated a number of PSCs with distinct …

Following implantation, the human embryo undergoes major morphogenetic transformations
that establish the future body plan. While the molecular events underpinning this process …

The pluripotency of mammalian early and late epiblast could be recapitulated by naïve
embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively …

During embryonic development, naive pluripotent epiblast cells transit to a formative state.
The formative epiblast cells form a polarized epithelium, exhibit distinct transcriptional and …

Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

Organoids are engineered 3D miniature tissues that are defined by their organ-like
structures, which drive a fundamental understanding of human development. However …

Growing human organs in animals sounds like something from the realm of science fiction,
but it may one day become a reality through a technique known as interspecies blastocyst …