Polymeric Nanoparticles as a Self‐Adjuvanting Peptide Vaccine Delivery System: The Role of Shape

P Koirala, SPR Chen, JC Boer, ZG Khalil… - Advanced Functional …, 2023 - Wiley Online Library
Antigens incorporated in subunit vaccines are typically poorly immunogenic, so a strong
immunostimulant (adjuvant) and/or delivery system is required to boost immunogenicity. In …

Swelling‐Induced Symmetry Breaking: A Versatile Approach to the Scalable Production of Colloidal Particles with a Janus Structure

J Qiu, Z Chen, M Chi, Y Xia - … Chemie International Edition, 2021 - Wiley Online Library
Janus particles are widely sought for applications related to colloidal assembly, stabilization
of emulsions, and development of active colloids, among others. Here we report a versatile …

Water-borne nanocoating for rapid inactivation of SARS-CoV-2 and other viruses

VA Bobrin, SP Chen, CF Grandes Reyes, B Sun… - ACS …, 2021 - ACS Publications
The rise in coronavirus variants has resulted in surges of the disease across the globe. The
mutations in the spike protein on the surface of the virion membrane not only allow for …

Designing molecular building blocks for functional polymersomes

SJ Rijpkema, BJ Toebes, MN Maas… - Israel Journal of …, 2019 - Wiley Online Library
In recent years various polymeric vesicles have been reported that show promising results
for drug delivery applications, nanomotors and/or nanoreactors. These polymeric vesicles …

Exploiting PET-RAFT polymerization mediated by cross-linked zinc porphyrins for the thermo-sensitive regulation of poly (N-isopropylacrylamide-b-acrylamide)

F Li, Y Yu, H Lv, Y Wan, X Gao, Y Li, Y Zhang - European Polymer Journal, 2022 - Elsevier
A series of thermo-sensitive block copolymers poly (N-isopropylacrylamide-b-acrylamide)(P
(NIPAm-b-AM)) are prepared via photoinduced electron/energy transfer-reversible addition …

Trithiocarbonates in RAFT polymerization

G Moad - RAFT Polymerization: Methods, Synthesis and …, 2021 - Wiley Online Library
This chapter provides a review of the synthesis, reactions, and applications of
trithiocarbonates, R′ SC ( S) SR, in radical polymerization with reversible addition …

Review of Shape Transformation Pathways of Polymersomes: Implications for Nanomotor, Biomedicine, and Artificial Cell Mimics

X Zhang, JCM van Hest, Y Men - ACS Applied Nano Materials, 2024 - ACS Publications
Polymersomes have been studied for many years since their discovery, and have
consistently been an appealing and widely explored research domain. Their inherent …

RGD Density on Tadpole Nanostructures Regulates Cancer Stem Cell Proliferation and Stemness

D Zhang, B Sun, J Wang, SPR Chen… - …, 2024 - ACS Publications
Cancer stem cells (CSCs) make up a small population of cancer cells, primarily responsible
for tumor initiation, metastasis, and drug resistance. They overexpress Arg-Gly-Asp (RGD) …

Surface Inactivation of Highly Mutated SARS-CoV-2 Variants of Concern: Alpha, Delta, and Omicron

VA Bobrin, SPR Chen, CF Grandes Reyes… - …, 2022 - ACS Publications
Continued SARS-CoV-2 transmission among the human population has meant the evolution
of the virus to produce variants of increased infectiousness and virulence, coined variants of …

Therapeutic delivery of polymeric tadpole nanostructures with high selectivity to triple negative breast cancer cells

VA Bobrin, Y Lin, J He, Y Qi, W Gu… - …, 2020 - ACS Publications
Targeted delivery of therapeutic drugs using nanoparticles to the highly aggressive triple
negative breast cancer cells has the potential to reduce side effects and drug resistance …