From hemoglobin allostery to hemoglobin-based oxygen carriers
Hemoglobin (Hb) plays its vital role through structural and functional properties
evolutionarily optimized to work within red blood cells, ie, the tetrameric assembly, well …
evolutionarily optimized to work within red blood cells, ie, the tetrameric assembly, well …
The Molecular Size of Bioengineered Oxygen Carriers Determines Tissue Oxygenation in a Hypercholesterolemia Guinea Pig Model of Hemorrhagic Shock and …
Polymerized human hemoglobin (PolyhHb) has shown promise in preclinical hemorrhagic
shock settings. Different synthetic and purification schemes can control the size of PolyhHbs …
shock settings. Different synthetic and purification schemes can control the size of PolyhHbs …
Scalable production and complete biophysical characterization of poly (ethylene glycol) surface conjugated liposome encapsulated hemoglobin (PEG-LEH)
Particle encapsulated hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) have clear
advantages over their acellular counterparts because of their larger molecular diameter and …
advantages over their acellular counterparts because of their larger molecular diameter and …
Core–Shell Structured Hemoglobin Nanoparticles as Artificial O2 Carriers
W Okamoto, M Hasegawa, N Kohyama… - ACS Applied Bio …, 2022 - ACS Publications
This paper describes the synthesis and O2 binding properties of core–shell structured
hemoglobin (Hb) nanoparticles (NPs), artificial O2 carriers of five types, as designed for use …
hemoglobin (Hb) nanoparticles (NPs), artificial O2 carriers of five types, as designed for use …
Pilot scale production and characterization of next generation high molecular weight and tense quaternary state polymerized human hemoglobin
CT Cuddington, SR Wolfe, DA Belcher… - Biotechnology and …, 2022 - Wiley Online Library
Polymerized human hemoglobin (PolyhHb) is being studied as a possible red blood cell
(RBC) substitute for use in scenarios where blood is not available. While the oxygen (O2) …
(RBC) substitute for use in scenarios where blood is not available. While the oxygen (O2) …
Controlled polymerization and ultrafiltration increase the consistency of polymerized hemoglobin for use as an oxygen carrier
DA Belcher, CT Cuddington, EL Martindale… - Bioconjugate …, 2019 - ACS Publications
Polymerized human hemoglobins (PolyhHbs) are a promising class of red blood cell
substitute for use in transfusion medicine. Unfortunately, the application of the commonly …
substitute for use in transfusion medicine. Unfortunately, the application of the commonly …
The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study
DA Belcher, JA Ju, JH Baek, A Yalamanoglu… - PLoS …, 2018 - journals.plos.org
A major constraint in the treatment of cancer is inadequate oxygenation of the tumor mass,
which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human …
which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human …
Polymerized human hemoglobin facilitated modulation of tumor oxygenation is dependent on tumor oxygenation status and oxygen affinity of the hemoglobin-based …
Administration of hemoglobin-based oxygen carriers (HBOCs) into the systemic circulation is
a potential strategy to relieve solid tumor hypoxia in order to increase the effectiveness of …
a potential strategy to relieve solid tumor hypoxia in order to increase the effectiveness of …
Synthesis of hemoglobin-based oxygen carrier nanoparticles by desolvation precipitation
Hemoglobin (Hb)-based oxygen carriers (HBOCs) present an alternative to red blood cells
(RBCs) when blood is not available. However, the most widely used synthesis techniques …
(RBCs) when blood is not available. However, the most widely used synthesis techniques …
Quaternary structure analysis of a hemoglobin core in hemoglobin–albumin cluster
Y Morita, T Yamada, M Kureishi, K Kihira… - The Journal of …, 2018 - ACS Publications
A core–shell ensemble of bovine hemoglobin (Hb) and human serum albumin (HSA) is an
artificial O2 carrier as a red blood cell substitute. This protein particle is created by covalent …
artificial O2 carrier as a red blood cell substitute. This protein particle is created by covalent …