Objectives The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
to date, the epidemic has gradually spread to 209 countries worldwide with more than 1.5 …

Nowadays, it is vital to have new, complete, and rapid methods to screen and follow
pharmacotoxicological and forensic cases. In this context, an important role is undoubtedly …

The primary cause of poor and ambiguous results obtained from the bioanalytical process is
the sample pre-treatment, especially in clinical analysis because it involves dealing with …

Background The accurate measurement of plasma levels of antibiotics is crucial for the
individualization of antimicrobial therapies based on PK/PD strategies. In this paper we …

The world is currently overwhelmed by a novel coronavirus disease (COVID-19). Clinically,
COVID-19 shows a broad range of manifestations: from asymptomatic to severe and …

Potential under-or overdose of antibiotics may occur in intensive care units due to high
variability in plasma concentrations. The risk is either treatment failure or toxicity. Thus …

Antimicrobial resistance (AMR) is a major threat to global health due to the wide use of
antibacterial drugs. Multiple studies show that the pharmacokinetic/pharmacodynamic …

Pharmacokinetics/pharmacodynamics is the foundation for guiding the rational application
of antibiotics in clinical practice, so it is necessary to establish quantitative methods for …

Empirically prescribed standard dosing regimens of antibacterial agents may result in
insufficient or excess plasma concentrations with persistently poor clinical outcomes …

Systemic antifungal agents are essential for high-risk patients undergoing
immunosuppressive therapy or cancer chemotherapy because of the rapid increase in …