Members of the Prdm family are characterized by an N-terminal PR domain that is related to
the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific …

B lymphocyte–induced maturation protein-1 (Blimp-1), discovered 16 years ago as a
transcriptional repressor of the IFNβ promoter, plays fundamentally important roles in many …

T cell exhaustion is common during chronic infections and can prevent optimal immunity.
Although recent studies have demonstrated the importance of inhibitory receptors and other …

Blimp1, a zinc-finger containing DNA-binding transcriptional repressor, functions as a
master regulator of B cell terminal differentiation. Considerable evidence suggests that …

The changing pattern of granulosa cell expression of inhibin/activin subunits and follistatin
during follicle development and their differential regulation by extrinsic and intraovarian …

Our understanding of the neural crest, a key vertebrate innovation, is built upon studies of
multiple model organisms. Early research on neural crest cells (NCCs) was dominated by …

Molecular pathways that control the specification, migration, and number of available
smooth muscle progenitor cells play key roles in determining blood vessel size and …

This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne
and isotretinoin's mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin …

Mice with a T cell–specific deletion of Prdm1, encoding Blimp-1, have aberrant T cell
homeostasis and develop fatal colitis. In this study, we show that one critical activity of Blimp …

Epigenetic mechanisms play an essential role in the germline and imprinting cycle. Germ
cells show extensive epigenetic programming in preparation for the generation of the …