Serotonin was first discovered in the gut, and its conventional actions as an intercellular
signalling molecule in the intrinsic and extrinsic enteric reflexes are well recognized, as are …

Elevated circulating levels of glucocorticoids are associated with psychiatric symptoms
across several different conditions. It remains unknown if this hormonal abnormality is a …

The lifespan of people with severe mental illness (SMI) is shorter compared to the general
population. This excess mortality is mainly due to physical illness. We report prevalence …

Context Most previous studies have examined suicide risk in relation to a single physical
disease. Objectives To estimate relative risk across a range of physical diseases, to assess …

Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B receptor
(TrkB) are expressed in human osteoblasts and mediate fracture healing. BDNF/TrkB …

Use of antidepressant medications that act on the serotonin system has been linked to
detrimental impacts on bone mineral density (BMD), and to osteoporosis. This article …

Telomere length has been hypothesized to be a marker of cumulative exposure to stress,
and stress is an established cause of depression and anxiety disorders. The aim of this …

As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

Background Depression and frailty both predict disability and morbidity in later life. However,
it is unclear to what extent these common geriatric syndromes represent overlapping …

OBJECTIVE: To systematically review the peer-reviewed literature regarding the effects of
self-administered mind-body therapies on menopausal symptoms. METHODS: To identify …