Trager and Jensen established a method for culturing Plasmodium falciparum, a
breakthrough for malaria research worldwide. Since then, multiple attempts to establish …

Lipoic acid-modified proteins are essential for central metabolism and pathogenesis. In
recent years, the Escherichia coli and Bacillus subtilis lipoyl assembly pathways have been …

Coenzyme A (CoA) biosynthesis is an excellent target for antimalarial intervention. While
most studies have focused on the use of CoA to produce acetyl-CoA in the apicoplast and …

Lipoic acid is an organosulfur cofactor essential for several key enzyme complexes in
oxidative and one-carbon metabolism. It is covalently bound to the lipoyl domain of the E2 …

Lipoic acid is synthesized by a remarkably atypical pathway in which the cofactor is
assembled on its cognate proteins. An octanoyl moiety diverted from fatty acid synthesis is …

To thrive, vector-borne pathogens must survive in the vector's gut. How these pathogens
successfully exploit this environment in time and space has not been extensively …

Lipoic acid (LA) is a sulfur‐containing cofactor covalently attached to key enzymes of central
metabolism in prokaryotes and eukaryotes. LA can be acquired by scavenging, mediated by …

Lipoic acid is a conserved cofactor necessary for the activation of several critical enzyme
complexes in the aerobic metabolism of 2-oxoacids and one-carbon metabolism. Lipoate …

Lipoate is a redox active cofactor that is covalently bound to key enzymes of oxidative
metabolism. Plasmodium falciparum is auxotrophic for lipoate during the intraerythrocytic …

Staphylococcus aureus competes for myriad essential nutrients during host infection. One of
these nutrients is the organosulfur compound lipoic acid, a cofactor required for the activity …