Mitochondria participate in crucial cellular processes such as energy harvesting and
intermediate metabolism. Although mitochondria possess their own genome—a vestige of …

Mitochondria generate adenosine 5′-triphosphate (ATP) and are a source of potentially
toxic reactive oxygen species (ROS). It has been suggested that the gradual mitochondrial …

The increased longevity of the C. elegans electron transport chain mutants isp-1 and nuo-6
is mediated by mitochondrial ROS (mtROS) signaling. Here we show that the mtROS signal …

The molecular mechanisms underlying the aging process have garnered much attention in
recent decades because aging is the most significant risk factor for many chronic diseases …

In Caenorhabditis elegans, the programmed repression of the heat shock response (HSR)
accompanies the transition to reproductive maturity, leaving cells vulnerable to …

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple
species including worms, flies and mice. Here, we study three C. elegans mitochondrial …

Mild inhibition of mitochondrial respiration extends the lifespan of many species. In
Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating …

Sustained mitochondrial fitness relies on coordinated biogenesis and clearance. Both
processes are regulated by constant targeting of proteins into the organelle. Thus …

The human population is aging, and the need for interventions to slow progression of age-
related diseases (geroprotective interventions) is growing. Repurposing compounds already …

Paraquat (methyl viologen), is a non-selective contact herbicide and well known
mitochondrial toxicant. Mitochondria are the center of cellular metabolism, and involved in …