Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting
up to 1% of the general population. Its prevalence exponentially increases with age and …

Atrial fibrillation (AF) is the most frequent arrhythmia and is associated with substantial
morbidity and mortality. Pathophysiological aspects consist in the activation of pro-fibrotic …

Background: ZFHX3 (zinc finger homeobox 3), a gene that encodes a large transcription
factor, is at the second-most significantly associated locus with atrial fibrillation (AF), but its …

The use of fresh tissue for molecular studies is preferred but often impossible. Instead,
frozen or formalin-fixed, paraffin-embedded (FFPE) tissues are widely used and constitute …

In search of more efficacious and safe pharmacological treatments for atrial fibrillation (AF),
atria-selective antiarrhythmic agents have been promoted that target ion channels …

A deeper knowledge of the dynamic transcriptional activity of promoters and enhancers is
needed to improve mechanistic understanding of the pathogenesis of heart failure and heart …

The Wnt signaling pathway regulates physiological processes such as cell proliferation and
differentiation, cell fate decisions, and stem cell maintenance and, thus, plays essential roles …

Fibronectin type III domain-containing protein 5 (FNDC5) exerts potential anti-arrhythmic
effects. However, the function and mechanism of FNDC5 in diabetes-associated atrial …

Atrial fibrillation (AF) is an abnormal heart rhythm characterized by rapid and irregular
beating of the atria. The non-coding RNAs (ncRNAs) have attracted much attention of AF …

Background: Atrial fibrillation (AF) often arises from structural abnormalities in the left atria
(LA). Annotation of the noncoding genome in human LA is limited, as are effects on gene …