Role of hydroxytyrosol and oleuropein in the prevention of aging and related disorders: focus on neurodegeneration, skeletal muscle dysfunction and gut microbiota

L Micheli, L Bertini, A Bonato, N Villanova, C Caruso… - Nutrients, 2023 - mdpi.com
Aging is a multi-faceted process caused by the accumulation of cellular damage over time,
associated with a gradual reduction of physiological activities in cells and organs. This …

Extra virgin olive oil (EVOO), a Mediterranean diet component, in the management of muscle mass and function preservation

S Salucci, A Bartoletti-Stella, A Bavelloni, B Aramini… - Nutrients, 2022 - mdpi.com
Aging results in a progressive decline in skeletal muscle mass, strength and function, a
condition known as sarcopenia. This pathological condition is due to multifactorial …

Optimization of Ultrasonic-Assisted Extraction of Major Phenolic Compounds from Olive Leaves (Olea europaea L.) Using Response Surface Methodology

J Giacometti, G Žauhar, M Žuvić - Foods, 2018 - mdpi.com
The ultrasound-assisted extraction (UAE) of oleuropein (OLE), verbascoside (VER), and
luteolin-4′-O-glucoside (L4OG), as the major phenolics from olive leaves, was optimized …

Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing

R Grewal, M Reutzel, B Dilberger, H Hein, J Zotzel… - Experimental …, 2020 - Elsevier
As components of the Mediterranean diet (MedDiet) olive polyphenols may play a crucial
role for the prevention of Alzheimer's disease (AD). Since mitochondrial dysfunction is …

Therapeutic effects of olive and its derivatives on osteoarthritis: From bench to bedside

KY Chin, KL Pang - Nutrients, 2017 - mdpi.com
Osteoarthritis is a major cause of morbidity among the elderly worldwide. It is a disease
characterized by localized inflammation of the joint and destruction of cartilage, leading to …

Oleuropein prevents neuronal death, mitigates mitochondrial superoxide production and modulates autophagy in a dopaminergic cellular model

I Achour, AM Arel-Dubeau, J Renaud… - International journal of …, 2016 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder, primarily affecting
dopaminergic neurons in the substantia nigra. There is currently no cure for PD and present …

Transcriptomic Analysis of Colorectal Cancer Cells Treated with oil production Waste products (OPWPs) reveals Enrichment of pathways of mitochondrial functionality

M Leo, L Muccillo, E Pranzini, G Barisciano, M Parri… - Cells, 2022 - mdpi.com
Oil production waste products (OPWPs) derive from olive mill and represent a crucial
environmental problem due to their high polyphenolic content able to pollute the ground …

A peptide isolated from Hippocampus abdominalis improves exercise performance and exerts anti-fatigue effects via AMPK/PGC-1α pathway in mice

Y Zhang, B Ryu, Y Cui, C Li, C Zhou, P Hong… - Journal of Functional …, 2019 - Elsevier
Seahorse is been used as a traditional Chinese medicine and invigorant for many years.
Among, the seahorse is considered to have anti-fatigue effects. However, few researches …

Oleuropein isolated from Fraxinus rhynchophylla inhibits glutamate-induced neuronal cell death by attenuating mitochondrial dysfunction

MH Kim, JS Min, JY Lee, U Chae, EJ Yang… - Nutritional …, 2018 - Taylor & Francis
Glutamate-induced neurotoxicity is related to excessive oxidative stress accumulation and
results in the increase of neuronal cell death. In addition, glutamate has been reported to …

In silico investigation of uncoupling protein function in avian genomes

P Davoodi, M Ghaderi-Zefrehei… - Frontiers in Veterinary …, 2023 - frontiersin.org
Introduction The uncoupling proteins (UCPs) are involved in lipid metabolism and belong to
a family of mitochondrial anionic transporters. In poultry, only one UCP homologue has been …