Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

Albumin is filtered through the glomerulus with a sieving coefficient of 0.00062, which results
in approximately 3.3 g of albumin filtered daily in human kidneys. The proximal convoluted …

Recent molecular insights have established the podocyte as a key component of the
glomerular filtration barrier, and hence an important common pathway in proteinuric …

NPHS2 was recently identified as a gene whose mutations cause autosomal recessive
steroid-resistant nephrotic syndrome. Its product, podocin, is a new member of the stomatin …

Diabetic nephropathy seems to occur as a result of an interaction of metabolic and
haemodynamic factors. Glucose dependent pathways are activated within the diabetic …

We studied the distribution of nephrin in renal biopsies from 17 patients with diabetes and
nephrotic syndrome (7 type 1 and 10 type 2 diabetes), 6 patients with diabetes and …

Chronic kidney disease (CKD) occurs in all age groups, including children. Regardless of
the underlying cause, CKD is characterized by progressive scarring that ultimately affects all …

Proteinuria is a poorly understood feature of many acquired renal diseases. Recent studies
concerning congenital nephrotic syndromes and findings in genetically modified mice have …

Glomerular diseases remain the leading cause of chronic and end-stage kidney disease.
Significant advances in our understanding of human glomerular diseases have been …

Dysfunction of slit diaphragm, a cell–cell junction of glomerular podocytes, is involved in the
development of proteinuria in several glomerular diseases. Slit diaphragm should be a …