Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

H Liu, Y Yu, A Dong, M Elsabahy, YW Yang… - Exploration, 2024 - Wiley Online Library
Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium
nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived …

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Z Wang, W Sun, R Hua, Y Wang, Y Li… - International Journal of …, 2024 - nature.com
Despite decades of research, cancer continues to be a major global health concern. The
human mouth appears to be a multiplicity of local environments communicating with other …

Fecal microbiota transplantation inhibits colorectal cancer progression: Reversing intestinal microbial dysbiosis to enhance anti-cancer immune responses

H Yu, XX Li, X Han, BX Chen, XH Zhang… - Frontiers in …, 2023 - frontiersin.org
Many lines of evidence demonstrate the associations of colorectal cancer (CRC) with
intestinal microbial dysbiosis. Recent reports have suggested that maintaining the …

Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota

M Chen, W Lin, N Li, Q Wang, S Zhu, A Zeng… - Frontiers in …, 2022 - frontiersin.org
Colorectal cancer (CRC) ranks third in terms of global incidence and second in terms of
death toll among malignant tumors. Gut microbiota are involved in the formation …

Deciphering the mechanism of Peptostreptococcus anaerobius-induced chemoresistance in colorectal cancer: the important roles of MDSC recruitment and EMT …

J Gu, X Lv, W Li, G Li, X He, Y Zhang, L Shi… - Frontiers in …, 2023 - frontiersin.org
Peptostreptococcus anaerobius (P. anaerobius, PA) in intestinal flora of patients with
colorectal cancer (CRC) are associated with poor prognosis. Studies have shown that P …

Parvimonas micra can translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma

K Conde‐Pérez, E Buetas, P Aja‐Macaya… - Molecular …, 2024 - Wiley Online Library
Oral and intestinal samples from a cohort of 93 colorectal cancer (CRC) patients and 30
healthy controls (non‐CRC) were collected for microbiome analysis. Saliva (28 non‐CRC …

The multispecies microbial cluster of Fusobacterium, Parvimonas, Bacteroides and Faecalibacterium as a precision biomarker for colorectal cancer diagnosis

K Conde‐Pérez, P Aja‐Macaya, E Buetas… - Molecular …, 2024 - Wiley Online Library
The incidence of colorectal cancer (CRC) has increased worldwide, and early diagnosis is
crucial to reduce mortality rates. Therefore, new noninvasive biomarkers for CRC are …

From the colon to the liver: how gut microbiota may influence colorectal cancer metastatic potential

I Mignini, G Piccirilli, L Galasso, F Termite… - Journal of Clinical …, 2024 - mdpi.com
The gut microbiota's influence on human tumorigenesis is a burning topic in medical
research. With the new ontological perspective, which considers the human body and its …

The emerging role of hypoxia and environmental factors in inflammatory bowel disease

LB Villareal, X Xue - Toxicological Sciences, 2024 - academic.oup.com
Inflammatory bowel disease (IBD) is a chronic and debilitating disorder characterized by
inflammation of the gastrointestinal tract. Despite extensive research, the exact cause of IBD …

Integrating Transcriptomics and Metabolomics to Explore the Novel Pathway of Fusobacterium nucleatum Invading Colon Cancer Cells

X Wu, J Xu, X Yang, D Wang, X Xu - Pathogens, 2023 - mdpi.com
Colorectal cancer (CRC) is a malignancy with a very high incidence and mortality rate
worldwide. Fusobacterium nucleatum bacteria and their metabolites play a role in inducing …