• Exercise changes the abundance of a number of important metabolites and substrates to
keep our muscles contracting.• These metabolites may serve as substrates to enable …

The dengue virus and related flaviviruses are an increasing global health threat. In this
perspective, we comment on and review medicinal chemistry efforts aimed at the prevention …

Estimates of the quality of experimental maps are important in many stages of structure
determination of macromolecules. Map quality is defined here as the correlation between a …

X-ray crystallography is an established method for studying the structure of proteins and
other macromolecules. As the importance of proteins grows, researchers in many fields have …

Publisher Summary The software packages SOLVE and RESOLVE comprise a suite for an
automated structure solution using multiple isomorphous replacement (MIR) …

Molecular docking uses the three-dimensional structure of a receptor to screen a small
molecule database for potential ligands. The dependence of docking screens on the …

Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved
proteins in living organisms. AHCY catalyzes the reversible break of S …

SnB is a direct-methods program based on the Shake-and-Bake methodology. It has been
used to solve difficult or large structures that could not be solved by traditional reciprocal …

The inositol 1, 4, 5-trisphosphate (IP 3) receptors (IP 3 Rs) are IP 3-gated Ca 2+ channels on
intracellular Ca 2+ stores. Herein, we report a novel protein, termed IRBIT (IP 3 Rbinding …

In mammals, S-adenosylhomocysteine hydrolase (AdoHcyase) is the only known enzyme to
catalyze the breakdown of S-adenosylhomocysteine (AdoHcy) to homocysteine and …