Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology

SJ Forrester, GW Booz, CD Sigmund… - Physiological …, 2018 - journals.physiology.org
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The extracellular matrix in ischemic and nonischemic heart failure

NG Frangogiannis - Circulation research, 2019 - Am Heart Assoc
The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

A review on anaerobic co-digestion with a focus on the microbial populations and the effect of multi-stage digester configuration

A Rabii, S Aldin, Y Dahman, E Elbeshbishy - Energies, 2019 - mdpi.com
Recent studies have shown that anaerobic co-digestion (AnCoD) is superior to conventional
anaerobic digestion (AD). The benefits of enhanced bioenergy production and solids …

The extracellular matrix in myocardial injury, repair, and remodeling

NG Frangogiannis - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
The cardiac extracellular matrix (ECM) not only provides mechanical support, but also
transduces essential molecular signals in health and disease. Following myocardial …

Umbilical cord-derived mesenchymal stem cell-derived exosomal microRNAs suppress myofibroblast differentiation by inhibiting the transforming growth factor-β …

S Fang, C Xu, Y Zhang, C Xue, C Yang… - Stem cells …, 2016 - academic.oup.com
Excessive scar formation caused by myofibroblast aggregations is of great clinical
importance during skin wound healing. Studies have shown that mesenchymal stem cells …

The potential role of miRNAs in the pathogenesis of cardiovascular diseases–A focus on signaling pathways interplay

EG Khidr, AI Abulsoud, AA Doghish… - … -Research and Practice, 2023 - Elsevier
For the past two decades since their discovery, scientists have linked microRNAs (miRNAs)
to posttranscriptional regulation of gene expression in critical cardiac physiological and …

Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease

D Santovito, C Weber - Nature Reviews Cardiology, 2022 - nature.com
Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Glioblastoma-associated microglia reprogramming is mediated by functional transfer of extracellular miR-21

ER Abels, SLN Maas, L Nieland, Z Wei, PS Cheah… - Cell reports, 2019 - cell.com
Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in
the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their …

MicroRNAs in heart failure: from biomarker to target for therapy

EL Vegter, P van der Meer, LJ de Windt… - European journal of …, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are increasingly recognized to play important roles in cardiovascular
diseases, including heart failure. These small, non‐coding RNAs have been identified in …

[HTML][HTML] Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling

MA Horn, AW Trafford - Journal of molecular and cellular cardiology, 2016 - Elsevier
Cardiovascular disease is a leading cause of death worldwide and there is a pressing need
for new therapeutic strategies to treat such conditions. The risk of developing cardiovascular …