Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

During the development of the mammalian central nervous system, neural stem cells and
their derivative progenitor cells generate neurons by asymmetric and symmetric divisions …

The precursor function of the ubiquitous glial cell type in the developing central nervous
system (CNS), the radial glia, is largely unknown. Using Cre/loxP in vivo fate mapping …

Primary cilia are key sensory organelles that are thought to be disassembled prior to mitosis.
Inheritance of the mother centriole, which nucleates the primary cilium, in relation to …

Apical plasma membrane constituents of mammalian neural stem/progenitor cells have
recently been implicated in maintaining their stem/progenitor cell state. Here, we report that …

Neocortical precursor cells undergo symmetric and asymmetric divisions while producing
large numbers of diverse cortical cell types. In Drosophila, cleavage plane orientation …

Early in development of the central nervous system, radial glial cells arise from the
neuroepithelial cells lining the ventricles around the time that neurons begin to appear. The …

Expansion of the neocortex requires symmetric divisions of neuroepithelial cells, the primary
progenitor cells of the developing mammalian central nervous system. Symmetrically …

Cerebral cortical progenitor cells can be classified into several different types, and each
progenitor type integrates cell-intrinsic and cell-extrinsic cues to regulate neurogenesis. On …

Circletail is one of only two mouse mutants that exhibit the most severe form of neural tube
defect (NTD), termed craniorachischisis. In this disorder, almost the entire brain and spinal …