ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Recent extensive evidence indicates that air pollution, in addition to causing respiratory and
cardiovascular diseases, may also negatively affect the brain and contribute to central …

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

In the adult mammalian hippocampus, new neurons arise from stem and progenitor cell
division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive …

There has been significant advancement in various aspects of scientific knowledge
concerning the role of cerebellum in the etiopathogenesis of autism. In the current …

The protective/neurotoxic role of fractalkine (CX3CL1) and its receptor CX3C chemokine
receptor 1 (CX3CR1) signaling in neurodegenerative disease is an intricate and highly …

Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of
patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal …

DNA methylation is a covalent chemical modification of DNA catalyzed by DNA
methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing …

Recent studies have deepened our understanding of multiple mechanisms by which
extracellular matrix (ECM) molecules regulate various aspects of synaptic plasticity and …

Although the critical role for epigenetic mechanisms in development and cell differentiation
has long been appreciated, recent evidence reveals that these mechanisms are also …