Nervous systems are arguably the most fascinating and complex structures in the known
universe. How they are built, changed by experience and then degenerate are some of the …

Cell death plays an important role both in shaping the developing nervous system and in
neurological disease and traumatic injury. In spite of their name, death receptors can trigger …

'Epigenetic age acceleration'is a valuable biomarker of ageing, predictive of morbidity and
mortality, but for which the underlying biological mechanisms are not well established. Two …

Inhibition of soluble epoxide hydrolase (SEH), the enzyme responsible for degradation of
vasoactive epoxides, protects against cerebral ischemia in rats. However, the molecular and …

Despite the importance of microRNAs (miRs) for regulation of the delicate balance between
cell proliferation and death, evidence for their specific involvement during death receptor …

Photoreceptor apoptosis is a critical process of retinal degeneration in retinitis pigmentosa
(RP), a group of retinal degenerative diseases that result from rod and cone photoreceptor …

Activation of tumor necrosis factor receptor-1 can trigger survival or apoptosis pathways. In
many cellular models, including the neuronal cell model PC12, it has been demonstrated …

Dermo disease, caused by Perkinsus marinus, is one of the most severe diseases of eastern
oysters, Crassostrea virginica. It causes serious mortalities in both wild and aquacultured …

Cells and tissues are continuously subject to environmental insults, such as heat shock and
oxidative stress, which cause the accumulation of cytotoxic, aggregated proteins. We …

The importance of death receptor (DR) signaling in embryonic development and
physiological homeostasis is well established, as is the existence of several molecules that …