In the past decade, nonalcoholic fatty liver disease (NAFLD) has become a leading cause of
chronic liver disease and cirrhosis, as well as an important risk factor for hepatocellular …

Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of
death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Obesity-associated inflammation stems from a combination of cell-intrinsic changes of
individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune …

Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …

The prevalence of obesity is a major cause of many chronic metabolic disorders, including
type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and cancer. Insulin …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …

Obesity-related insulin resistance is driven by low-grade chronic inflammation of metabolic
tissues. In the liver, nonalcoholic fatty liver disease (NAFLD) is associated with hepatic …

The immune response requires major changes to metabolic processes, and indeed, energy
metabolism and functional activation are fully integrated in immune cells to determine their …

In obesity, inflammation of white adipose tissue (AT) is associated with diminished
generation of beige adipocytes ('beige adipogenesis'), a thermogenic and energy …