Abstract Process Systems Engineering (PSE) is the scientific discipline of integrating scales
and components describing the behavior of a physicochemical system, via mathematical …

The rise of personalised and highly complex drug product profiles necessitates significant
advancements in pharmaceutical manufacturing and distribution. Efforts to develop more …

This review provides a deep analysis of the different methodologies to improve the operation
of solar thermal plants based on mathematical optimization. The various schemes found in …

Aiming to significantly improve their processes and secure market share, monoclonal
antibody (mAb) manufacturers seek innovative solutions that will yield improved production …

Batch processes are inevitably affected by disturbances. The process control system can
often reject them and ensure that the final product is “in spec.” Nevertheless, processing …

Simultaneous evaluation of multiple time scale decisions has been regarded as a promising
avenue to increase the process efficiency and profitability through leveraging their …

Integrated scheduling and control (SC) seeks to unify the objectives of the various layers of
optimization in manufacturing. This work investigates combining scheduling and control …

The batch process plays an important role in various fields of industrial production. Among
them, the production processes that have specific requirements for operational continuity in …

In order to minimize operation transient times, a new distributed control strategy was
performed in a distillation unit. Acting simultaneously by heating in tray 11 (stripping …

Unlike other parts of this book, this chapter does not deal with mathematical procedures for
modeling complex reaction systems, for example, strategies for construction/reduction of …