Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

Background Intestinal fibrosis resulting in stricture formation and obstruction in Crohn's
disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is …

The ovary is indispensable for female reproduction, and its age-dependent functional
decline is the primary cause of infertility. However, the molecular basis of ovarian aging in …

Introduction Crohn's disease (CD) is a complex disease, and assessing activity is
challenging due to pathobiologic process eg ECM remodeling, mucosal damage, and …

The bacterial ability to adhere and colonize in the gut is a key prerequisite to become a
probiotic. Lactobacillus spp. surface layer proteins (SLPs) play an important role for such …

The repair and regeneration of tissues and organs using engineered biomaterials has
attracted great interest in tissue engineering and regenerative medicine. Recent advances …

In steady state, intestinal subepithelial myofibroblasts form a thin layer below the basement
membrane. Unlike the rest of the stromal cells in the lamina propria, they express tensile …

Background and aims The stiffening of the extracellular matrix, and changes in its cellular
and molecular composition, have been reported in the pathogenesis of fibrosis. We analyze …

The intestine is home to an intertwined network of epithelial, immune, and neuronal cells as
well as the microbiome, with implications for immunity, systemic metabolism, and behavior …

Despite a number of studies providing evidence that the extracellular matrix (ECM) is an
active player in the pathogenesis of intestinal inflammation, knowledge on the actual …