Much evidence has accumulated in the literature over the last fifteen years that indicates
vitamin A has a role in metabolic disease prevention and causation. This literature proposes …

Retinoids are required for maintaining many essential physiological processes in the body,
including normal growth and development, normal vision, a healthy immune system, normal …

By definition, a vitamin is a substance that must be obtained regularly from the diet. Vitamin
A must be acquired from the diet, but unlike most vitamins, it can also be stored within the …

Absorption of a photon by an opsin pigment causes isomerization of the chromophore from
11-cis-retinaldehyde to all-trans-retinaldehyde. Regeneration of visual chromophore …

It is well established that chylomicron remnant (dietary) vitamin A is taken up from the
circulation by hepatocytes, but more than 80% of the vitamin A in the liver is stored in hepatic …

The liver is the most important tissue site in the body for uptake of postprandial retinoid, as
well as for retinoid storage. Within the liver, both hepatocytes and hepatic stellate cells …

Background: Excessive accumulation of retinol-based toxins has been implicated in the
pathogenesis of geographic atrophy (GA). Fenretinide, an orally available drug that reduces …

Past, present, and future research into hepatic stellate cells (HSCs, also called vitamin A-
storing cells, lipocytes, interstitial cells, fat-storing cells, or Ito cells) are summarized and …

Vitamin A is a micronutrient important for vision, cell growth, reproduction and immunity.
Both deficiency and excess consuming of vitamin A cause severe health consequences …

Vitamin A (retinol) is absorbed in the small intestine, stored in liver, and secreted into
circulation bound to serum retinol-binding protein (RBP4). Circulating retinol may be taken …